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Seroquel for Meth recovery
| christian |
Seroquel for METH recovery
it pays
to hang out near pubmed =] This is medical research new as of 1+
month
www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
1: Behav Brain Res. 2006 Sep 15;172(1):39-45. Epub 2006 May
19.Click here to read Links
The effects of chronic administration of quetiapine on the
methamphetamine-induced recognition memory impairment and
dopaminergic terminal deficit in rats.
* He J,
* Yang Y,
* Yu Y,
* Li X,
* Li XM.
Neuropsychiatry Research Unit, Department of Psychiatry,
University of Saskatchewan, 103 Wiggins Road, Saskatoon, Sask.,
Canada S7N 5E4.
Previous studies have suggested that quetiapine, a new atypical
antipsychotic drug, may have beneficial effects on cognitive
impairment and be a neuroprotectant in treating
neurodegenerative diseases. In the present study, we
investigated the therapeutic effects of chronic administration
of quetiapine on methamphetamine (METH)-induced recognition
memory impairment and dopaminergic terminal neurotoxicity in
rats. Rats were pretreated with METH (5 mg/kg; s.c.) four times
at 2-h intervals while their body temperature was monitored.
Fifteen minutes after the last METH injection, rats were
administered quetiapine (10 mg/kg/day; i.p.) for 28 days. One
day after the last quetiapine injection, rats were trained and
tested on an object recognition task on days 29 and 30. Finally,
on day 31, rats were sacrificed for immunohistochemistry, 1 day
after the object recognition task. METH induced hyperthermia,
recognition memory impairment and a decrease of tyrosine
hydroxylase immunoreactivity in the caudate putamen (CPu) of
striatum. Quetiapine attenuated the METH-induced
hyperthermia. Furthermore, chronic post-treatment of quetiapine
reversed the METH-induced memory impairment and dopaminergic
terminal deficit. These findings suggest that quetiapine may
have therapeutic effects in the treatment of cognitive
impairment and neurodegeneration induced by METH.
PMID: 16712969 [PubMed - indexed for MEDLINE] |
Rubyy
2zday |
Re: Seroquel for METH recovery
hmm... my
friend has been on a super high dose of seroquel for long time
for bi-polar personality disorder. She is 1 month clean from
meth. I will pass this on to her. It should also be mentioned
that seroquel is a heavy duty med with plenty of dangerous
side-effects, so as with all meds the benefits should be weighed
against the dangers. Dose and amount of time on it should be
regularly monitored and adjusted or decreased if possible, but
-like many meds- the longer you're on it, the higher dose
needed. Tricky situation.
|
sickids
gurl
|
Re: Seroquel for METH recovery
Ummmmmmmmmmmmmmmm, In English PLEASE...?????
BTW I was prescribed seroquil for insomnia. (probably meth
induced) |
Rubyy2
zday |
Re: Seroquel for METH recovery
... &
just how efficiently do tests on RATS translate to humans? |
Flea
Bay |
Re: Seroquel for METH recovery
good
additions Ruby and Sick.
Basically, the article is saying that Seroquel can repair damage
that meth does to your brain, which previously was though to not
be able to recover. So, i just though I would post this
information for anyone out there who is recovering, like myself.
You may want to show this to your doctor to try some yourself. |
Flea
Bay |
Re: Seroquel for METH recovery
well,
good point again Ruby. Cant say for sure.
But METH is shown to cause brain damage in both rats and humans
in a similar way, so I suspect this definitely points to MORE
studies being done to investigate this road, and could possibly
be proven to be a good new treatment for meth recoveries. |
| Sfj |
Re: Seroquel for METH recovery
The most
common side effect is sedation, and is prescribed specifically
(off-label) for this effect in patients with sleep disorders.
Seroquel will put the patient into a drowsy state, and will help
the patient fall asleep. It is one of the most sedating of all
anti psychotic drugs, rivaling even the most sedating older
antipsychotics. Many prescriptions call for the entire dose to
be taken before bedtime because of its sedative effects.
Although quetiapine is approved by the FDA for the treatment of
schizophrenia and bipolar disorder, it is frequently prescribed
for off-label purposes including insomnia or the treatment of
anxiety disorders. Due to its sedative side effects, reports of
quetiapine abuse (sometimes by insufflating crushed tablets)
have emerged in medical literature; for the same reason, abuse
of other antipsychotics, such as chlorpromazine (Thorazine), may
occur as well, but research related to the abuse of typical
antipsychotics is limited.
en.wikipedia.org/wiki/Quetiapine |
Flea
Bay |
Re: Seroquel for METH recovery
lol,
excellent info SFJ, i currently do not have a prescription, but
may be looking into getting some in the near future.
I don't think it will be hard to all to get a script if you tell
your doctor you are recovering meth user, since its definitely
not addictive (like a benzo or painkiller) and its not a huge
thing for doctors to give out really, as compared to Adderall,
or Vicodin, which a doctor must use great consideration to
prescribe. |
| Sfj |
Re: Seroquel for METH recovery
Our
clinic gives Seroquel to quite a number of recovering meth
users. Not as a cure for meth addiction, but rather to get them
more calm and sleeping regularly in early recovery.
I have no opinions on this. (not yet anyhow, I'm still learning) |
kmb
2006 |
Re: Seroquel for METH recovery
A little
more info. Seroquel is part of my hubby's bi-polar cocktail, but
his doc is taking the dosage down cause he's coming out of his
mania.
Quetiapine for treatment of alcohol dependence.
Long-term evaluation of the effect of quetiapine on
hallucinations, delusions and motor function in advanced
Parkinson disease.
www.crazymeds.org/seroquel.html |
Rubyy
2zday |
Re: Seroquel for METH recovery
There are
other much more serious side effects than sleepiness. This drug
impacts the liver (just like most meds) & recovering addicts may
need to be careful as the liver may be damaged. Here's some
other info:
Some side effects will have signs or symptoms that you can see
or feel. Your doctor may watch for others, such as changes in
the lenses of the eyes, by doing certain tests. Tardive
dyskinesia (a movement disorder) may occur and may not go away
after you stop using the medicine. Signs of tardive dyskinesia
include fine, worm-like movements of the tongue, or other
uncontrolled movements of the mouth, tongue, cheeks, jaw, or
arms and legs. Another serious side effect that may occur is the
neuroleptic malignant syndrome (NMS). You and your doctor should
discuss the good this medicine will do as well as the risks of
taking it. |
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